In this article, however, the researchers have studied the mechanisms by which Aspirin might be used to reduce liver damage caused by Tylenol (acetaminophen). According to the article, Tylenol accounts for most drug overdoses in the US. Upon reviewing the scientific journal article, the idea became a bit more clear. Hepatocyte (liver cell) death causes a cascade of events that lead to the release of inflammatory cytokines. The scientists in this study discovered it was free-floating DNA from apoptized cells that were the instigators of the cascades. According to the researchers, "The protective effect of aspirin on acetaminophen-induced liver injury was due to downregulation of proinflammatory cytokines." The true mechanism is still not fully undestood, but research has very important clinical implications.
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